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Page 1
Conflict of Interest Disclosures.
[No authors listed] [No authors listed] Global Spine J. 2023 May;13(2_suppl):568S-591S. doi: 10.1177/21925682231173597. Global Spine J. 2023. PMID: 37222100 Free PMC article. No abstract available.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
In general, our study suggests that bitopic ligands that engage the sodium ion-binding pocket in class A G-protein-coupled receptors can be designed to control their efficacy and functional selectivity profiles for G(i), G(o) and G(z) subtypes and arrestins, thus modulatin …
In general, our study suggests that bitopic ligands that engage the sodium ion-binding pocket in class A G-protein-coupled receptors can be …
The impact of mild hypoxia exposure on myokine secretion in human obesity.
van Meijel RLJ, Vliex LMM, Hartwig S, Lehr S, Al-Hasani H, Blaak EE, Goossens GH. van Meijel RLJ, et al. Int J Obes (Lond). 2023 Jun;47(6):520-527. doi: 10.1038/s41366-023-01294-5. Epub 2023 Mar 30. Int J Obes (Lond). 2023. PMID: 36997723 Clinical Trial.
RESULTS: Hypoxia exposure (1% O(2)) increased secreted protein acidic and rich in cysteine (SPARC, p = 0.043) and follistatin like 1 (FSTL1, p = 0.021), and reduced leukemia inhibitory factor (LIF) secretion (p = 0.009) compared to 3% O(2) in primary human myotubes. …
RESULTS: Hypoxia exposure (1% O(2)) increased secreted protein acidic and rich in cysteine (SPARC, p = 0.043) and follistatin like 1 …
A Relationship Between O-Serotype, Antibiotic Susceptibility and Biofilm Formation in Uropathogenic Escherichia coli.
Noie Oskouie A, Hasani A, Ahangarzadeh Rezaee M, Soroush Bar Haghi MH, Hasani A, Soltani E. Noie Oskouie A, et al. Microb Drug Resist. 2019 Jul/Aug;25(6):951-958. doi: 10.1089/mdr.2018.0330. Epub 2019 Feb 28. Microb Drug Resist. 2019. PMID: 30817229
Most isolates were resistant to cefotaxime, ceftazidime, and tetracycline, but maintained their sensitivity to imipenem. O(25), O(15), O(8), and O(75) were the most commonly detected serogroups. Moreover, O(25), O(15,) and O(8) wer …
Most isolates were resistant to cefotaxime, ceftazidime, and tetracycline, but maintained their sensitivity to imipenem. O(25), O …
Standard practice in the treatment of unstable pelvic ring injuries: an international survey.
Klingebiel FK, Hasegawa M, Parry J, Balogh ZJ, Sen RK, Kalbas Y, Teuben M, Halvachizadeh S, Pape HC, Pfeifer R; SICOT Trauma Research Group. Klingebiel FK, et al. Int Orthop. 2023 Sep;47(9):2301-2318. doi: 10.1007/s00264-023-05859-x. Epub 2023 Jun 17. Int Orthop. 2023. PMID: 37328569 Free PMC article.
Rescue screws (RS), C-clamps (CC), angioembolization (AE), and pelvic packing (PP) were observed to be rarely implemented in practice (A + O: RS = 24%, CC = 25%, AE = 21%, PP = 25%). External fixation was the most common method temporized fixation (A + O = 71%). Per …
Rescue screws (RS), C-clamps (CC), angioembolization (AE), and pelvic packing (PP) were observed to be rarely implemented in practice (A + …
50 results